physician photo

David C. Linehan, MD

  • Chief, Section of Hepatobiliary-Pancreatic and Gastrointestinal Surgery
  • Professor of Surgery

Medical School

University of Massachusetts, Worcester, MA, 1990

Post Doctoral Education

Fellowship: Laboratory Biologic Cancer Therapy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 1995

Residency: Deaconess-Harvard Surgical Service, Harvard Medical School, Boston, MA, 1997

Fellowship: Kristen Ann Carr Fellow in Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, 1999

Board Certifications

Surgery--Certified

Honors and Awards

2011, Listed in Best Doctors in America, (Best Doctors, Inc.)

2004, Evarts A. Graham Teaching Award, Washington University School of Medicine

Clinical Interests

Benign and malignant surgical treatment of diseases of the bile duct, gallbladder, gastrointestinal tract, liver, and pancreas, soft tissue sarcoma, tumor immunology, multimodality treatment of cancer, vaccine therapy for cancer

Research Interests

Tumor immunology and the basic biology of tumor-associated immune suppression

Development of novel vaccine strategies for the tratment of pancreas cancer

Plasma proteomics in pancreas cancer

Current Research Funding

Phase I Study of Single Dose Neoadjuvant Zometa in Patients with Resectable Pancreas Cancer. Supported by Novartis Investigator Initiated Research Grant, 2009-2011

Blockade of Myeloid Derived Suppressor Cell Mobilization for the Treatment of Pancreas Cancer. Supported by Siteman Cancer Center Foundation, 2010-2011

Patients Seen At

Center for Advanced Medicine
GI Center
4921 Parkview Place, Suite C, Floor 8
St. Louis, MO 63110
(314) 747-2938
Fax: (314) 222-6255

Contact Information

Washington University School of Medicine
Department of Surgery
Section of Hepatobiliary Pancreatic Surgery
Campus Box 8109, 660 S. Euclid Ave.
St. Louis, MO 63110

Selected Publications

Pub Med Directory for David C. Linehan, M.D.

Gnerlich JL, Mitchem JB, Weir JS, Sankpa NV, Kashiwagi H, Belt BA, Porembka MR, Herndon JM, Eberlein TJ, Goedegebuure P, Linehan DC. Induction of Th 17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J Immunol. 2010 Oct 1;185(7):4063-71.

Callery MP, Chang KJ, Fishman EK, Talamonti MS, Traverso WL, Linehan DC. Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement. Ann Surg Oncol. 2009 Apr 24.

Moo-Young TA, Larson JW, Belt BA, Tan MC, Hawkins WG, Eberlein TJ, Goedegebuure PS, Linehan DC. Tumor derived TGF-Beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer. J Immunother. 2009 Jan;32(1):12-21.

Linehan DC, Tan MCB, Strasberg SM, Drebin JA, Hawkins WG, Picus J, Myerson RJ, Malyapa RS, Hull M, Trinkaus K, Tan BR Jr. Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study. Ann Surg. 2008; 248(2): 145-151.

Viehl CT, Moore TT, Liyanage UK, Frey DM, Ehlers JP, Eberlein TJ, Goedegebuure PS, Linehan DC. Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer bearing mice. Ann Surg Oncol. 2006;13(9):1252-1258.

Lin Y, Goedegebuure PS, Tan MC, Gross J, Malone JP, Feng S, Larson J, Phommaly C, Trinkaus K, Townsend RR, Linehan DC. Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients. J Proteome Res. 2006;5:2169-2176.

Liyanage UK, Moore TT, Viehl CT, Ehlers JP, Eberlein TJ, Goedegebuure PS, and Linehan DC. Increased prevalence of regulatory T Cells induced by pancreas adenocarcinoma. J Immunother. 2006; 29:416-424.

Lin LL, Picus J, Drebin JA, Linehan DC, Solis J, Strasberg SM, Tan B, Thorstad WL, Myerson R. A Phase II study of alternating cycles of split course radiation therapy and gemcitabine chemotherapy for inoperable pancreatic or biliary tract adenocarcinoma. Am J Clin Oncol. 2005; 28:234-241.

Linehan DC and Goedegebuure PS. Regulatory T Cells in Cancer. Immunologic Research. 2005; 32:155-168.

Strasberg SM. Drebin JA. Linehan DC. Radical antegrade modular pancreatosplenectomy. Surgery. 2003;133:521-7.

Tan MC, Goedegebuure PS, Belt BA, Flaherty B, Sankpal N, Gillanders WE, Eberlein TJ, Hsieh CS, Linehan DC. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol. 2009 Feb 1;182(3):1746-55.

Linehan DC, Goodegebuure PS, Eberlein TJ. Vaccine therapy for cancer: A review. Ann Surg Oncol. 1996;3:219-228.

Linehan DC, Goedegebuure PS, Peoples GE, Rogers SO, Eberlein TJ. Tumor-specific and HLA-A2 restricted cytolysis by tumor-associated lymphocytes in human metastatic breast cancer. J Immunol. 1995;155:4486-4491.

Linehan DC, Peoples GE, Goedegebuure PS, Hess DT, Summerhayes IC, Parikh AS, Eberlein TJ. In vitro stimulation of ovarian tumor-associated lymphocyte with a peptide derived from HER2/neu induces cytotoxicity against autologous tumor. Surg Oncol. 1995;4:41-50.

Editorial Positions

Archives of Surgery, Editor
Journal of Immunology, Ad hoc reviewer
Clinical Cancer Research, Ad hoc reviewer
Cancer Immunology and Immunotherapy, Ad hoc reviewer
Blood, Ad hoc reviewer
Annals of Surgical Oncology, Ad hoc reviewer
Journal of the American College of Surgeons, Ad hoc reviewer
American Journal of Surgery, Ad hoc reviewer

Chapters

Linehan DC, Jarnagin WR. Benign Tumors and Pseudotumors of the Biliary Tract. In: Blumgart LH (Editor-in-Chief). Surgery of the Liver, Biliary Tract and Pancreas. 4th edition. Philadelphia: Elsevier;2005.

Strasberg SM and Linehan DC. Tumors of the Liver, Biliary Tract and Pancreas. In: Souba WW, Fink MP, Jurkovich et al. (eds.). ACS Surgery Online: Principles & Practice. New York: WebMD, Inc.; 2005. http://www.acssurgery.com

Linehan DC and Jarnagin WR. Benign Tumors and Pseudotumors of the Biliary Tract. In: Blumgart LH, Editor-in-Chief. Surgery of the Liver, Biliary Tract and Pancreas. 4th edition. Philadelphia: Elsevier; 2006.

Strasberg SM and Linehan DC. Radiofrequency Ablation of Hepatic Tumors. In: Current Problems in Surgery. 2003;40(8):459-498. Mosby, St. Louis.

Strasberg SM and Linehan DC. Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy. In: Malignant Liver Tumors: Current and Emerging Therapies. Chicago: Bartlet and Barnes; 2002.

Linehan DC, Amos K, Eberlein TJ. Active Immunotherapy. In: Souba WW and Wilmore DW (eds.). Surgical Research. San Diego: Academic Press; 2001.

Linehan DC and Brennan MF. Soft Tissue Sarcoma. In: Holzheimer RG and Mannick JA (eds.). Surgical Treatment: Evidence-based and Problem Oriented. Munich: W. Zuckschwerdt Verlag; 2001.